Adenosine is a purine nucleoside base, most commonly recognized with the molecule adenosine triphosphate, or ATP, and is used thoroughly throughout the entire body in general metabolism.[6]

Adenosine’s use as a pharmacological drug works through receptors called purinergic adenosine receptors found throughout the body. During sleep, adenosine is recycled and levels are reduced in the brain; less adenosine receptor stimulation leads to more alertness. In essence, the longer you’re awake, the more adenosine you accumulate, the more sleep pressure you acquire, and the more likely you can fall asleep at bedtime.

How does adenosine affect sleep?
How Adenosine Affects Sleep. An increase in adenosine increases a person’s need for sleep, also called sleep drive or sleep pressure. The sleep drive helps the body maintain sleep-wake homeostasis, or the right amount of sleep and wakefulness over time.

Does adenosine make you sleep?

Therefore, adenosine is proposed to act as a homeostatic regulator of sleep and to be a link between the humoral and neural mechanisms of sleep-wake regulation. Both the adenosine A(1) receptor (A(1)R) and A(2A)R are involved in sleep induction.
Why does adenosine make me sleepy?
As adenosine builds up in the bloodstream, it interacts with specific cell receptors, inhibiting neural activity and causing drowsiness.


How do you increase adenosine for sleep?
Adenosine increases during exercise as ATP is consumed for energy. This may contribute to the feeling of sleepiness after physical exertion. So if you have trouble falling asleep and want to increase adenosine, some researchers recommend a trip to the gym.
What happens if you have too much adenosine?
Short-term exposure to increased adenosine can reduce pain by reducing inflammation and relaxing blood vessels, whereas persistently high levels of the chemical lead to chronic inflammation and tissue damage.


Does caffeine block adenosine?
Over the course of a day, you get sleepy as adenosine binds to A1 receptors in your brain. Caffeine blocks adenosine from binding, thus making you feel alert and also helping you feel better. Caffeine is the most widely consumed psychoactive drug in the world, largely due to its mood-enhancing and stimulatory effects.


What are the cons of adenosine?
It can cause breathing problems and chest pain, particularly when given at high doses. Headache, heart pounding, low blood pressure, nausea, sweating, flushing, lightheadedness, sleep problems, coughing, and anxiety can also occur.
Who should not take adenosine?
Angina, unstable orUnstable heart or blood vessel problems (eg, cardiovascular instability)—Avoid use, as this medicine may increase the risk of a heart attack.


Does adenosine reduce anxiety?
Importantly, adenosine also appears to mediate some of the reinforcing effects of alcohol, including its well-known ability to reduce feelings of anxiety. Increased sensitivity to the rewarding or reinforcing effects of ethanol is associated with greater drinking.
Does napping clear adenosine?
A nap alone will naturally decrease the level of adenosine in your brain and body. But pair that with a shot of caffeine, and you can effectively kick the bulk of your slowdown chemical to the curb. Again: caffeine takes 20 minutes to kick in.


When should adenosine be avoided?
Adenosine is contraindicated in patients with sinus node disease, such as sick sinus syndrome or symptomatic bradycardia, and in patients with second or third-degree AV block, except in patients with a functioning artificial pacemaker.


How do you feel after adenosine?
Clinically, adenosine is an appropriate first-line agent; however, it is associated with several adverse effects. These effects include headache, dizziness, facial flushing, dyspnea, gastrointestinal distress, and neck discomfort


What foods are high in adenosine?
Grass-fed meat, pastured poultry, and organ meats, such as liver or kidneys. Wild-caught fish and seafood, such as salmon, sardines, halibut, orange roughy, tuna, ling, pike, cod, cusk, sunfish, haddock, and whitefish.


How can I increase my adenosine naturally?
Adenosine is a byproduct of cellular metabolism, so the more active and alert we are during the day, the more adenosine builds up in the brain. Exercise for example can increase brain adenosine levels and through stimulation of adenosine receptors promote sleep.


Does melatonin increase adenosine?
We find that melatonin promotes sleep downstream of the circadian clock as it is not required to initiate or maintain circadian rhythms. Additionally, we provide evidence that melatonin may induce sleep in part by promoting adenosine signaling, thus potentially linking circadian and homeostatic control of sleep.


Is adenosine bad for your heart?
While adenosine can slow conduction through the AV node, it does not affect accessory pathways. In such cases, this can cause severe tachycardia that can deteriorate to a non-perfusing rhythm, leading to cardiac arrest.


What chemical keeps you asleep?
Melatonin – a hormone released by the pineal gland – helps you feel sleepy once the lights go down. The peaks and valleys of melatonin (represented as the gold line above) are important for matching the body’s circadian rhythm to the external cycle of light and darkness.


Does adenosine cause brain fog?
One simple way to tell if you’re not getting enough sleep, Brennan said, is if you wake up feeling groggy. This is a sign that the sleep chemical adenosine, which makes us drowsy, has not fully cleared out of the body and that you’re in “sleep debt,” she explained.


How long does it take for adenosine to clear up?
Our bodies flush the built-up adenosine over the course of our night’s sleep, but the chemical residue doesn’t just disappear the moment we wake up–it takes a while (about 60-90 minutes for most of us) for the effects to burn off completely.
What behavior does adenosine affect?
In addition to their role in mood disorders, adenosine A1 and A2A receptors also regulate anxiety-like behavior. In particular, A2A receptors appear to be important in this regard. Adenosine receptors play an important role in sleep regulation and influence circadian clockwork.




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