A client brought this up so I wanted to do some research on Kisspeptin-10 and this is what I found. 

 a source- $52.00

a source -$59.00

What is kisspeptin 10 used for?
Kisspeptin plays a major role in the control of reproductive hormones in both men and women. Specifically, kisspeptin regulates the release of ‘gonadotrophin releasing hormone’ (GnRH) from the hypothalamus.
How often do you take kisspeptin?
Twice-weekly administration of kisspeptin-54 for 8 weeks stimulates release of reproductive hormones in women with hypothalamic amenorrhea.
What are the side effects of kisspeptin 10?
Kisspeptin was well tolerated, with no side effects or adverse events reported (eTable 4 in Supplement 2). In addition, kisspeptin had no significant clinical effects on blood pressure or heart rate (eFigure 5 in Supplement 2), as previously reported.Feb 3, 2023
What does kisspeptin hormone do?
Kisspeptin has been implicated in the regulation of puberty onset, ovarian function, trophoblast invasion, fertility regulation, parturition, and lactation. Thus, it may offer a potential treatment for reproductive disorders, characterized by low or high gonadotropins, such as IHH, HA, and PCOS.Apr 22, 2017
What is the role of kisspeptin in puberty?
Kisspeptin Controls GnRH Pulse Generation and Pubertal Onset
Increasing evidence suggests that hypothalamic kisspeptin [first named as metastin (25)] neurons play a key role in controlling pubertal onset via stimulation of GnRH/gonadotropin secretion in mammals.Apr 30, 2019
How long does it take for kisspeptin-10 to work?
Kisspeptin-10 dose-response study
Intravenous injections of kisspeptin-10 elicited a rapid increase in LH in all volunteers, with peak concentrations seen by 45 min after injection for all doses studied.
Where can I find kisspeptin?
Kisspeptin is a protein present in the hypothalamus (a part of the brain that controls the release of several important hormones in the body).
Where should you inject kisspeptin?
For injection, vial contents were reconstituted in 0.5 ml of 0.9% saline. Then a 0.5-ml insulin syringe was used to inject a weight-adjusted volume of dissolved vial contents into the lower anterior abdominal region.Nov 1, 2009
How does kisspeptin make you feel?
We demonstrate that kisspeptin administration enhances limbic responses to sexual and bonding stimuli and that this activity correlates with reward measures, improved positive mood, and reduced sexual aversion. In addition, kisspeptin attenuates negative mood.


Why do men take kisspeptin?

Administration of kisspeptin was reported to be well-tolerated and showed no clinical impact on heart rate or blood pressure. Therefore, the current study demonstrates that the administration of kisspeptin in men with HSDD can improve brain sexual activity and increases penile tumescence (swollen or becoming swollen, especially as a response to sexual arousal). in response to sexual stimuli.
Kisspeptin, made in the hypothalamus, is an important hormone that starts the release of several other hormones. Also called metastin, this interesting hormone is connected to puberty and may also help stop the spread of cancer. Does kisspeptin increase testosterone? Conclusions: Kisspeptin-10 boluses potently evoke LH secretion in men, and continuous infusion increases testosterone, LH pulse frequency, and pulse size. Kisspeptin analogues have therapeutic potential as regulators of LH and thus testosterone secretion.1 Jun 2011

Dosage for Kisspeptin 10

How to reconstitute Mix 2 ml water with each vial of KISSPEPTIN 10. Two full insulin syringes of water. Only mix one bottle of each at a time and keep refrigerated. Dosage: There are many different dosages for Kisspeptin depending on the results you are looking to get from this peptide. We have seen good results with a 300mcg split three times a week. 10iu of KISSPEPTIN 10 at least one hour after the last meal of the evening. it is recommended to take this peptide before bed if possible. Split over three days example Mon / Wed / Sat Each 10iu is 250mcg Ideally, your last meal should be a protein source like chicken, fish, lean steak and vegetables. A very small portion of carbs only.


Kisspeptin Injections

All subjects were trained in self-administration of sc injections by an investigator at the start of the study protocol. At the beginning of each week when injections were to be performed, a box containing unlabeled vials of freeze-dried saline or kisspeptin-54, alcohol wipes, saline vials, needles, and needle disposal bins was given to each subject. For injection, vial contents were reconstituted in 0.5 ml of 0.9% saline. Then a 0.5-ml insulin syringe was used to inject a weight-adjusted volume of dissolved vial contents into the lower anterior abdominal region. Subjects were instructed to refrigerate vials stored at home.


What is the Kisspeptin-10 peptide?

Kisspeptin-10 research suggests the peptide is an important mediator of endocrine signaling when a person hits puberty as well as during reproduction. It may affect the mood and behavior of a person and encourage the development and regulation of blood vessels and renal function, discouraging cancer cell proliferation and metastasis. Also known as Metastin, this peptide appears to affect the gonadotropin-releasing hormone or GnRH.[1]


AKA: KISS-1, Protein KISS-1, Metastin, Kp-10 peptide



MOLECULAR WEIGHT: 1302.4 g/mol



KISSPEPTIN-10 AND GONADOTROPIN-RELEASING HORMONES The Hypothalamus in the brain is responsible for the production and secretion of GnRH. It is secreted at the top of the hypothalamic-pituitary-gonadal axis. It controls the downstream production of follicle-stimulating hormone (FSH) and luteinizing hormones (LH). Primarily, these hormones are associated with the onset of puberty and the maturation of ova and sperm in the female and male reproductive organs, respectively. Administration of Kisspeptin has been studied for its potential to regulate menstruation and early-onset puberty and support certain cancer treatments.

KISSPEPTIN-10 AND TESTOSTERONE Due to Kisspeptin’s potential to affect the hypothalamic-pituitary-gonadal axis, the peptide may also affect levels of LH and FSH in the bloodstream. Studies observe this release brings about an almost 3x increase in testosterone concentration in males within hours of administration.[2] In addition, it the peptide has been suggested to hold potential in regulating the normal pulsatile release of sex hormones. These effects seem to be directly proportional to the amount of Kisspeptin administered. Kisspeptin is suggested to obscure individual pulses at extremely high doses, causing a continuous release of LH from the anterior pituitary glands. Thus, Kisspeptin-10 may have a  therapeutic potential for women during specific conditions arising during pregnancy and for individuals suffering from low testosterone levels.

KISSPEPTIN-10 AND ENERGY BALANCE A person’s nutritional or energetic status appears to affect the neurons secreting Kisspeptin-10, resulting in suppression of GnRH release. Extreme variations in this balance can cause infertility in both sexes.[3] Researchers conclude that “the novel role of kisspeptin neurons as active players within the neuronal circuits that govern energy balance is discussed, offering evidence of a bidirectional role of these neurons as a nexus between metabolism and reproduction.” Additionally, Kisspeptin may be responsible for the regulation of energy in an individual. Research has suggested that depleting the Kisspeptin receptor (Kiss1r)may augment lipid retention, simultaneously reducing energy consumption. Hence, Kisspeptin has the potential to help control the neurochemical status of an individual’s energy consumption and reproduction.

KISSPEPTIN-10 AND CANCER RESEARCH Kisspeptin appears to control the malignancy of melanomas very efficiently. This is possibly due to its proposed ability to affect the migration of the cancerous cells by reducing the adhesive capacity of these cells. Cancers affecting organs such as the breast, urinary bladder, gastrointestinal tract, prostate, pancreas, ovaries, skin, and thyroid appear to demonstrate reduced expression of Kisspeptin, which helps in metastasis. Kisspeptin has multiple potential effects other than those on tumor cells which limits its therapeutic usefulness. The peptide may potentially inhibit metastasis to other sites, thereby reducing disease burden and reducing mortality rates. Together, these effects may enable prescribed treatment plans to be executed fruitfully. Research has linked the levels of Kisspeptin and Melatonin to sunlight.[4] Also, some role has been established in suppressing cancerous growths, but not metastasis. Upon exposure to daylight, experimental models observed excess Kisspeptin and Melatonin production, and vice versa. When tumorigenic cells were introduced in these mice, heightened tumor growth and volume were seen upon daylight exposure.

KISSPEPTIN-10 AND MEMORY ENHANCEMENT In an individual, the memory consolidation and orientation in 3-D space also appear to be affected by Kisspeptin concentrations. Kisspeptin-10 analogs may have the potential to avert the negative effects of alcohol, such as learning disabilities and navigational impairment, due to their possible ability to regulate the neuronal function that is often affected in genetic or chronic learning disorders. Ongoing research suggests the potential of novel nootropics to help manage both health and affected brains for better functioning.

KISSPEPTIN-10 AND MOOD Reproduction, energy levels, and emotion affect one another. Researchers posit that reproduction and energy homeostasis is affected by Kisspeptin levels. Recent studies have also observed enhanced limbic brain activity such as increased reward-seeking behavior, enthusiasm, and general attitude with Kisspeptin administration.[5] Sexual and emotional processing gets linked to reproduction due to the apparent effect of Kisspeptin on mood, motivation, and sex drive in general.

KISSPEPTIN-10 AND KIDNEY, HEART Other than its role in controlling tumor metastasis, Kisspeptin appears to regulate kidney and heart function as well. Kisspeptin-10 and its receptors appear to be expressed in renal tissues, and studies have suggested that Kiss1 receptor knockouts fail to regulate glomerular development.[6] The scientists report that “Kisspeptins and kisspeptin receptor are altered in the kidney tissues of chronic renal impairment, raising the possibility of their pathophysiological roles in chronic renal failure.” Furthermore, Kisspeptin has been observed to control vasoconstriction and sometimes cardiac output in specific research settings.[7] Such regulation may be related to Kisspeptin’s potential to control vascular development and response to injury, the exact mechanism of which remains to be elucidated.

Kisspeptin-10 Summary

Kisspeptin’s potential in controlling tumor growth and metastasis has been well researched, possibly due to the peptide’s apparent involvement in vascular growth and functioning. In addition, Kisspeptin also appears to regulate hormone secretion related to human reproduction, testosterone levels, and sex-related behaviors like drive and motivation. One of its analogs, Kisspeptin-10, appears to be the safest per experimental research findings, with minimal reported side effects and acceptable oral and excellent subcutaneous bioavailability in mice. The per kg dosage applicable in mice models is not scalable in humans.


  1. Jayasena CN, Nijher GM, Comninos AN, Abbara A, Januszewki A, Vaal ML, Sriskandarajah L, Murphy KG, Farzad Z, Ghatei MA, Bloom SR, Dhillo WS. The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans. J Clin Endocrinol Metab. 2011 Dec;96(12):E1963-72. doi: 10.1210/jc.2011-1408. Epub 2011 Oct 5. PMID: 21976724; PMCID: PMC3232613.
  2. George JT, Veldhuis JD, Roseweir AK, Newton CL, Faccenda E, Millar RP, Anderson RA. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J Clin Endocrinol Metab. 2011 Aug;96(8):E1228-36. doi: 10.1210/jc.2011-0089. Epub 2011 Jun 1. PMID: 21632807; PMCID: PMC3380939.
  3. Navarro VM. Metabolic regulation of kisspeptin – the link between energy balance and reproduction. Nat Rev Endocrinol. 2020 Aug;16(8):407-420. doi: 10.1038/s41574-020-0363-7. Epub 2020 May 19. PMID: 32427949; PMCID: PMC8852368.
  4. Pazarci P, Kaplan H, Alptekin D, Yilmaz M, Lüleyap U, Singirik E, Pelit A, Kasap H, Yegani A. The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice. Croat Med J. 2020 Feb 29;61(1):55-61. doi: 10.3325/cmj.2020.61.55. PMID: 32118379; PMCID: PMC7063558.
  5. Comninos AN, Wall MB, Demetriou L, Shah AJ, Clarke SA, Narayanaswamy S, Nesbitt A, Izzi-Engbeaya C, Prague JK, Abbara A, Ratnasabapathy R, Salem V, Nijher GM, Jayasena CN, Tanner M, Bassett P, Mehta A, Rabiner EA, Hönigsperger C, Silva MR, Brandtzaeg OK, Lundanes E, Wilson SR, Brown RC, Thomas SA, Bloom SR, Dhillo WS. Kisspeptin modulates sexual and emotional brain processing in humans. J Clin Invest. 2017 Feb 1;127(2):709-719. doi: 10.1172/JCI89519. Epub 2017 Jan 23. PMID: 28112678; PMCID: PMC5272173.
  6. Shoji I, Hirose T, Mori N, Hiraishi K, Kato I, Shibasaki A, Yamamoto H, Ohba K, Kaneko K, Morimoto R, Satoh F, Kohzuki M, Totsune K, Takahashi K. Expression of kisspeptins and kisspeptin receptor in the kidney of chronic renal failure rats. Peptides. 2010 Oct;31(10):1920-5. doi: 10.1016/j.peptides.2010.07.001. Epub 2010 Jul 17. PMID: 20621140.
  7. Sato K, Shirai R, Hontani M, Shinooka R, Hasegawa A, Kichise T, Yamashita T, Yoshizawa H, Watanabe R, Matsuyama TA, Ishibashi-Ueda H, Koba S, Kobayashi Y, Hirano T, Watanabe T. Potent Vasoconstrictor Kisspeptin-10 Induces Atherosclerotic Plaque Progression and Instability: Reversal by its Receptor GPR54 Antagonist. J Am Heart Assoc. 2017 Apr 14;6(4):e005790. doi: 10.1161/JAHA.117.005790. PMID: 28411243; PMCID: PMC5533042.
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