As guys and women get older their testosterone and estrogen levels decrease. As a male athlete, LMT, and the kind of deep injury bodywork I do with athletes, I wanted to research this topic. My research is ongoing because of the complexity and wealth of information available.
Sources
Currently Reading: William Llewellyn’s book “Anabolics” 11th Edition
Finished Reading: Pat Lenehan’s book “Anabolic Steroids” a good introduction to steroids
https://en.wikipedia.org/wiki/Doping_in_sport
https://en.wikipedia.org/wiki/List_of_drugs_banned_by_WADA
https://www.dea.gov/drug-information/drug-scheduling
https://www.deadiversion.usdoj.gov/schedules/
https://www.ebmud.com/files/8914/3205/7862/common_controlled_alphabetically.pdf
STEROIDS – A COMPREHENSIVE GUIDE.
https://www.exchangesupplies.org/shopsect_steroids.php
A healthy heart pumps blood to the rest of the body, providing muscles and organs with the oxygen needed for peak performance. Testosterone helps red blood cell production through the bone marrow. Low testosterone levels are linked to a variety of cardiovascular risks.
But can testosterone replacement therapy help with heart disease? Study resultsTrusted Sources are mixed. Small studies in the early 2000s found that men with heart disease who underwent testosterone therapy saw only slight improvements. Some were able to increase their walking distance by 33 percent. Another study found that hormone therapy only widened healthy arteries but had no effect on angina pain.
A more recent, larger study of 83,000 men found that men whose testosterone levels returned to normal were 24 percent less likely to have a heart attack and 36 percent less likely to experience a stroke.
Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.[1][13] It belongs to a group of steroid hormones called the progestogens,[13] and is the major progestogen in the body. Progesterone has a variety of important functions in the body. It is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid.[14]
In addition to its role as a natural hormone, progesterone is also used as a medication, such as in combination with estrogen for contraception, to reduce the risk of uterine or cervical cancer, in hormone replacement therapy, and in feminizing hormone therapy.[15] It was first prescribed in 1934.[16]
- Eases anxiety.
- Promotes memory.
- Helps to prevent overgrowth of certain types of cells, which can help protect against some cancers including those of the breast or the uterus.
- Helps to prevent overgrowth of cells of the endometrial lining and prevent endometriosis from forming.
Progesterone level (ng/mL)
Normal levels are less than 0.20 ng/mL. Keep in mind that results can vary between laboratories. If you’re unsure about your test results, contact your healthcare provider.
https://en.wikipedia.org/wiki/Corticosteroid
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids, and mineralocorticoids, are involved in a wide range of physiological processes, including stress response, immune response, and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior.[1]
Some common naturally occurring steroid hormones are cortisol (C
21H
30O
5), corticosterone (C
21H
30O
4), cortisone (C
21H
28O
5) and aldosterone (C
21H
28O
5). (Note that cortisone and aldosterone are isomers.) The main corticosteroids produced by the adrenal cortex are cortisol and aldosterone.[2]
An Androgen (from Greek and-, the stem of the word meaning “man”) is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.[1] This includes the embryological development of the primary male sex organs and the development of male secondary sex characteristics at puberty. Androgens are synthesized in the testes, the ovaries, and the adrenal glands.
Androgens increase in both males and females during puberty.[2] The major androgen in males is testosterone.[3] Dihydrotestosterone(DHT) androstenedione are of equal importance in male development.[3] DHT in utero causes differentiation of the penis, scrotum, and prostate. In adulthood, DHT contributes to balding, prostate growth, and sebaceous gland activity.
Although androgens are commonly thought of only as male sex hormones, females also have them, but at lower levels: they function in libido and sexual arousal. Also, androgens are the precursors to estrogens in both men and women.
https://en.wikipedia.org/wiki/Sex_hormone
In general, androgens are considered “male sex hormones”, since they have masculinizing effects, while estrogens and progestogens are considered “female sex hormones”[5] although all types are present in each sex at different levels. Sex steroids include androgens, estrogens, and progestogens. Androgens are generally considered as the male sex hormones because of their masculinizing effects They include androstenediol, androstenedione, dehydroepiandrosterone, dihydrotestosterone, and testosterone
In addition to their role as natural hormones, androgens are used as medications; for information on androgens as medications, see the androgen replacement therapy and anabolic steroid articles.
Brain
Circulating levels of androgens can influence human behavior because some neurons are sensitive to steroid hormones. Androgen levels have been implicated in the regulation of human aggression and libido. Indeed, androgens are capable of altering the structure of the brain in several species, including mice, rats, and primates, producing sex differences.[12]
Numerous reports have shown androgens alone are capable of altering the structure of the brain,[13] but identification of which alterations in neuroanatomy stem from androgens or estrogens is difficult, because of their potential for conversion.
https://en.wikipedia.org/wiki/Estrogen
Estrogen or oestrogen, is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). Estradiol, an estrane, is the most potent and prevalent. Another estrogen called estetrol (E4) is produced only during pregnancy.
Estrogens are synthesized in all vertebrates[1] and some insects.[2] Their presence in both vertebrates and insects suggests that estrogenic sex hormones have an ancient evolutionary history. Quantitatively, estrogens circulate at lower levels than androgens in both men and women.[3] While estrogen levels are significantly lower in males than in females, estrogens nevertheless have important physiological roles in males.[4]
Like all steroid hormones, estrogens readily diffuse across the cell membrane. Once inside the cell, they bind to and activate estrogen receptors (ERs) which in turn modulate the expression of many genes.[5] Additionally, estrogens bind to and activate rapid-signaling membrane estrogen receptors (mERs),[6][7] such as GPER (GPR30).[8]
In addition to their role as natural hormones, estrogens are used as medications, for instance in menopausal hormone therapy, hormonal birth control, and feminizing hormone therapy for transgender women and nonbinary people.
- Fluoxymesterone (Halotestin), or “Halo”
- Mesterolone (Proviron)
- Methandienone (Dianabol), or “Dbol”
- Methyltestosterone (Virilon)
- Mibolerone (Cheque)
- Oxandrolone (Anavar, Oxandrin), or “Var”
- Oxymetholone (Anadrol), or “Drol”
- Stanozolol (Winstrol), or “Winny”
…
They include:
- Fluoxymesterone (Halotestin), or “Halo”
- Mesterolone (Proviron)
- Methandienone (Dianabol), or “Dbol”
- Methyltestosterone (Virilon)
- Mibolerone (Cheque)
- Oxandrolone (Anavar, Oxandrin), or “Var”
- Oxymetholone (Anadrol), or “Drol”
- Stanozolol (Winstrol), or “Winny”
- Depo-Testosterone (testosterone cypionate)
- Delatestryl (testosterone enanthate)
- Aveed (testosterone undecanoate)
- Testopel (testosterone pellet)
- Ditate-DS (testosterone enanthate)
- Depo-Testadiol (estradiol cypionate; testosterone cypionate)
Free Testosterone
Fact: Low testosterone can affect your appearance. Testosterone plays a critical role in developing muscle bulk. Studies say lack of this male hormone may cause decreased muscle mass and decreased facial hair growth. “Low T” can also lead to increased body fat and over-developed breasts in men.
Male hypogonadism is a condition in which the body doesn’t produce enough of the hormone that plays a key role in masculine growth and development during puberty (testosterone) or enough sperm or both. You can be born with male hypogonadism, or it can develop later in life, often from injury or infection.
It is possible for athletes to over-train and causes a drop in levels of testosterone. Endocrinologist Dr. Dolores Shoback looks at low T and explores testosterone supplementation. Recorded on 03/07/2018
| Age | Male (in ng/dl) | Female (in ng/dl) |
|---|---|---|
| 17 to 18 years | 300-1,200 | 20-75 |
| 19 years and older | 240-950 | 8-60 |
Better libido
Men with higher levels of testosterone usually have greater sexual activity. Older men need more testosterone for libido and erectile function. But it’s important to note that erectile dysfunction is often due to other conditions or medications rather than low testosterone levels.
Men with testosterone levels between 200 and 400 ng/dL are borderline and should have additional testing before considering therapy, and men with levels above 400 ng/dL don’t need further tests or therapy.
- Reduced sex drive.
- Reduced erectile function.
- Loss of body hair.
- Less beard growth.
- Loss of lean muscle mass.
- Feeling very tired all the time (fatigue)
- Obesity (being overweight)
- Symptoms of depression.
-
Low Testosterone
- Intramuscular injections, given anywhere from two to 10 weeks apart.
- Testosterone gel applied to the skin or inside the nose. AndroGel is one of the most-used medical products to treat Low T. The blockbuster gel is prescribed as a testosterone-replacement drug, mostly to men whose bodies fail to produce sufficient amounts of the male hormone.
- Mucoadhesive material applied above the teeth twice a day.
- Long-acting subcutaneous pellet.
- Testosterone stick (apply like underarm deodorant)
- Exercise and Lift Weights. …
- Eat Protein, Fat, and Carbs. …
- Minimize Stress and Cortisol Levels. …
- Get Some Sun or Take a Vitamin D Supplement. …
- Take Vitamin and Mineral Supplements. …
- Get Plenty of Restful, High-Quality Sleep.
- D-Aspartic Acid. D-Aspartic acid is a natural amino acid that can boost low testosterone levels. …
- Vitamin D. Vitamin D is a fat-soluble vitamin that your body produces upon exposure to sunlight. …
- Tribulus Terrestris. …
- Fenugreek. …
- Ginger. …
- DHEA. …
- Zinc. …
- Ashwagandha.
- Tuna. Tuna is rich in vitamin D, which has been linked to a longer life and testosterone production. …
- Low-fat milk with vitamin D. Milk is a great source of protein and calcium. …
- Egg yolks. …
- Fortified cereals. …
- Oysters. …
- Shellfish. …
- Beef. …
- Beans.
Some foods, vitamins, and herbs can help boost your testosterone levels. Be sure to talk to your doctor, if you’re concerned about low testosterone. These alternative and natural treatments aren’t proven to be more, or as, effective as traditional testosterone therapy. Some may also interact with any medications you may be taking and cause unintended side effects.
| Herbs | Vitamins and supplements | Foods |
| Malaysian ginseng | vitamin D | garlic |
| puncturevine | dehydroepiandrosterone (DHEA) | tuna |
| ashwagandha | L-arginine | egg yolks |
| pine bark extract | zinc | oysters |
| yohimbe | ||
| saw palmetto |
Yohimbe is the name of an evergreen tree found in parts of central and western Africa. The bark of Yohimbe contains a chemical called yohimbine, which is used to make medicine. Yohimbine hydrochloride (Aphrodyne, Yocon) is a form of yohimbine that is a prescription drug in the US.
Yohimbe supplements often list Yohimbe bark extract or yohimbine as the active ingredient. However, some of these products might not provide accurate information about the amount of yohimbine in the supplement. Also, some Yohimbe supplements list yohimbine hydrochloride as an active ingredient. Yohimbe products containing man-made yohimbine hydrochloride as an ingredient are not legal to sell as a dietary supplement in the US.
https://www.livestrong.com/article/206041-what-is-a-safe-dose-for-yohimbe/
Yohimbe is most commonly used for its hallucinogenic effects. It is also used for sexual problems, to boost mood, for athletic performance, and other conditions, but there is no good scientific evidence to support any use.
No quality research exists on Yohimbe bark, so safe and effective dosages are not clearly established, according to eMedTV. The website suggests beginning with the lowest dosage recommended on the product label. If you experience side effects, you may want to reduce the dosage. If the product does not work effectively, you can increase the dosage, but not more than advised on the label. The usual dose of the drug yohimbine is 15 to 30 mg daily in divided doses, according to the Swedish Medical Center. Some people experience optimal effectiveness at much lower doses, even as low as 5 mg daily. Taking a higher dose of Yohimbe does not necessarily produce better effectiveness, and some individuals will not experience significant benefits for up to three weeks of treatment.
Warning
Yohimbe bark extract can cause many side effects, as noted by the U.S. National Institutes of Health on its MedlinePlus website. They include skin flushing, decreased appetite, dizziness, headache, irritability, nervousness, and insomnia. High doses of the chemical yohimbine can cause serious side effects, some of which could occur if you take too much Yohimbe. This is much less likely than it is with the prescription drug since the yohimbine content of Yohimbe bark extract is generally low. High doses of yohimbine can lead to breathing difficulty, muscle aches, nausea, vomiting, diarrhea, painful urination, genital pain, anxiety, agitation, and tremors.
- Soy products. Soy foods, such as tofu, edamame, and soy protein isolates, contain phytoestrogens. …
- Dairy products. …
- Alcohol. …
- Mint. …
- Bread, pastries, and desserts. …
- Licorice root. …
- Certain fats.
- TestoPrime – Strongest Testosterone Booster. A 100% natural, safe, and effective daily testosterone supplement. …
- Testogen – Ideal for Men Over 40. …
- Testo-Max – Best for Muscle Growth. …
- Prime Male – Best Customer Service. …
- TestRX – Helps Improve Libido.
Testosterone Therapy in Females
Clenbuterol
https://www.medicalnewstoday.com/articles/319927
Clenbuterol is a steroid-like chemical that was initially developed to treat asthma in horses, working by relaxing the airways in the animals’ lungs.
Clenbuterol stimulates both the heart and central nervous system. It has a similar effect on the body as epinephrine and amphetamines.
It is also a beta-2-agonist, which is the opposite of a beta-blocker. While a beta-blocker will reduce the production of epinephrine and noradrenaline, clenbuterol increases it.
This increase will lead to a variety of effects, such as:
- rapid fat burning
- excitability
- nervousness
- increased energy
- greater determination
Also, clenbuterol contains dopamine, which is commonly known as the reward hormone. Dopamine is closely associated with addiction. As such, clenbuterol can be highly addictive.
In many countries, clenbuterol is banned from being used in animals that will be consumed by humans.
In 1994, 140 people in Spain were hospitalized after eating meat tainted by clenbuterol. Similarly, in 2006, 336 people in China were poisoned after eating pork that contained it.
Clenbuterol can reduce the amount of potassium naturally occurring in the body. Consequently, those taking it as a drug will often also eat an increased amount of bananas to replace the potassium.
Athletes will often accompany the taking of clenbuterol alongside a diet that is high in protein, moderate in carbohydrates, and low in fat.
The use of Clenbuterol among ladies has turned out to be trending well known as of recently. Big-name news stories and magazines specify it as a medication utilized for weight reduction by those in Hollywood. Along these lines, numerous ladies around the globe are taking a gander at it regardless of whether this supplement is alright for them to utilize.
It is known to be a stimulant to the body’s sensory system, which can be powerful in a weight reduction cycle.
In a few nations, individuals have endorsed the supplement for asthma.
Yixin Anavar
http://oncologyforwomen.org/health-library/hw-view.php?DOCHWID=d00566a1
GENERIC NAME(S): OXANDROLONE – brand names Oxandrin. Oxandrolone is classified as a controlled substance under the Anabolic Steroids Control Act of 1990 and has been assigned to Schedule III.
https://en.wikipedia.org/wiki/Oxandrolone
This medication is used to help people regain the weight they have lost due to certain medical conditions (such as surgery, chronic infection, trauma, long-term use of corticosteroid medication such as hydrocortisone/prednisone). It is also used to relieve bone pain due to bone loss (osteoporosis). Oxandrolone belongs to a class of drugs known as anabolic steroids. These drugs are similar to male hormones made by the body. Take this medication by mouth usually 2 to 4 times daily or as directed by your doctor.
Oxandrolone, sold under the brand names Oxandrin and Anavar, among others, is an androgen and anabolic steroid (AAS) medication that is used to help promote weight gain in various situations, to help offset protein catabolism caused by long-term corticosteroid therapy, to support recovery from severe burns, to treat bone pain associated with osteoporosis, to aid in the development of girls with Turner syndrome, and for other indications.[4][5][6] It is taken by mouth.[4]
Side effects of oxandrolone include symptoms of masculinization such as acne, increased hair growth, voice changes, and increased sexual desire.[4] The drug is a synthetic androgen and anabolic steroid hence is an agonist of the androgen receptor (AR), the biological target of androgens such as testosterone and dihydrotestosterone.[4][7] It has strong anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women.[4]
Oxandrolone was first described in 1962 and was introduced for medical use in 1964.[4] It is used mostly in the United States.[4][8] In addition to its medical use, oxandrolone is used to improve physique and performance.[4][9] The drug is a controlled substance in many countries, so nonmedical use is generally illicit.[4][10][11][12]
Many bodybuilders and athletes use oxandrolone for its muscle-building effects.[4] It is much more anabolic than androgenic, so women and those seeking less intense steroid regimens use it particularly often.[4] Many also value oxandrolone’s low hepatotoxicity relative to most other orally active AAS.[4]
Powerlifters have also been known to take oxandrolone, due to its ability to significantly increase muscular strength.[19]
…
Specifically, Anvarol may form a stack with the following supplements:
- Winsol.
- Trenorol.
- Clenbutrol.
Metenolone Enanthate – Primobolan – PRIMO
https://en.wikipedia.org/wiki/Metenolone_enanthate
Metenolone enanthate, or methenolone enanthate, sold under the brand names Primobolan Depot and Nibal Injection, is an androgen and anabolic steroid (AAS) medication that is used mainly in the treatment of anemia due to bone marrow failure.[2][3][4][5][6][7] It is given by injection into muscle.[6] Although it was widely used in the past, the drug has mostly been discontinued and hence is now mostly only available on the black market. [5][6][3] A related drug, metenolone acetate, is taken by mouth.[6]
Side effects of metenolone enanthate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire.[6] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).[6][8] It has moderate anabolic effects and weak androgenic effects, as well as no estrogenic effects or risk of liver damage.[6][8] Metenolone enanthate is a metenolone ester and a long-lasting prodrug of metenolone in the body.[6]
Metenolone enanthate was introduced for medical use in 1962.[6] In addition to its medical use, metenolone enanthate is used to improve physique and performance.[6] The drug is a controlled substance in many countries and so non-medical use is generally illicit.[6] It remains marketed for medical use only in a few countries, such as Spain and Turkey.[5][6]
https://en.wikipedia.org/wiki/Metenolone_acetate
Metenolone acetate, or methenolone acetate, sold under the brand names Primobolan and Nibal, is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure.[1][2][3][4][5][6] It is taken by mouth.[5] Although it was widely used in the past, the drug has mostly been discontinued and hence is now mostly no longer available.[4][5][2] A related drug, metenolone enanthate, is given by injection into muscle.[5]
Side effects of metenolone acetate include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire.[5] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).[5][7] It has moderate anabolic effects and weak androgenic effects, as well as no estrogenic effects or risk of liver damage.[5][7] Metenolone enanthate is a metenolone ester and a prodrug of metenolone in the body.[5]
Metenolone acetate was introduced for medical use in 1961.[8][5] In addition to its medical use, metenolone acetate is used to improve physique and performance.[5] The drug is a controlled substance in many countries and so non-medical use is generally illicit.[5] It remains marketed for medical use only in a few countries, such as Japan and Moldova.[4][5]
https://www.medicalnewstoday.com/articles/327242#are-they-safe
https://en.wikipedia.org/wiki/Hypoactive_sexual_desire_disorder
Medication
Approved
Flibanserin was the first medication approved by the FDA for the treatment of HSDD in premenopausal women. Its approval was controversial and a systematic review found its benefits to be marginal.[14] The only other medication approved in the US for HSDD in pre-menopausal women is bremelanotide, in 2019.[2]
Off-label
A few studies suggest that the antidepressant, bupropion, can improve sexual function in women who are not depressed if they have HSDD.[15] The same is true for the anxiolytic, buspirone, which is a 5-HT1A receptor agonist similar to flibanserin.[16]
Testosterone supplementation is effective in the short term.[17] However, its long-term safety is unclear.[17]
Testosterone therapy is more controversial in females than in males.
Normal total testosterone levels in healthy adult females are 15–70 ng/dl. Low testosterone in females can cause fertility problems, irregular periods, vaginal dryness, and a low sex drive. Despite this, doctors do not often recommend testosterone injections to treat low testosterone in females, as they can have masculinizing effects.
However, doctors may recommend testosterone therapy to help with hypoactive sexual desire disorder in females after menopause. Research has not supported their use for other signs and symptoms that people may experience after menopause, which include anxiety, mood changes, weight gain, and reduced bone density.
Currently, the FDA has not approved any products for testosterone therapy in females. Additionally, in the USA, there are no readily available formulations that provide the recommended treatment dose of 300 micrograms per day for females. As a result, a female will typically need a compounding pharmacy to fill the prescription.
Symptoms of low testosterone in women can include:
Trouble sleeping. Overall strength decrease. Muscle tone is reduced. Weight gain, especially around the middle.
Side effects of women taking testosterone
Balding. Deepening of the voice. Excessive hair growth, particularly on the face. Enlargement of the clitoris, a part of the outside of a woman’s genitals.
Many people believe that masturbation affects a man’s testosterone levels, but this is not necessarily true. Masturbation does not seem to have any long-lasting effects on testosterone levels. However, masturbation may have short-term effects on the levels of this hormone.
Prescription testosterone treatments are available as gels, skin patches, and intramuscular injections. Each comes with potential side effects. Patches can irritate the skin. Intramuscular injections may cause mood swings. If you use the gel, don’t share the product with others.
Possible side effects of testosterone therapy include:
- increased acne
- fluid retention
- increased urination
- breast enlargement
- decreased testicular size
- decreased sperm count
- increased aggressive behaviors
Testosterone treatment is not advised for men with prostate or breast cancer. Additionally, testosterone therapy may worsen sleep apnea in older people.
More on Low Testosterone
Thanks and Credit to John P. Mulhall, MD, and Calendar Bhasin, MD
While the number of men seeking testosterone treatment has tripled over the past decade, many patients who need hormone replacement for a testosterone deficiency are not receiving it.1 When low T occurs because of poor functioning testes or a tumor on the pituitary gland, for example, the result may be hypogonadism.
Recognizing this trend has led to the publication of guidelines for the diagnosis and management of testosterone deficiency in men by the American Urological Association1 (AUA) and an updated best practice recommendation from the Endocrine Society.2
“The use of testosterone therapy has increased dramatically in relatively healthy men without a clear indication of testosterone deficiency (low T), while other men in need of testosterone therapy fail to receive it due to clinician concerns regarding cardiovascular events or the development of prostate cancer,” says John P. Mulhall, MD, director of the Male Sexual and Reproductive Medicine Program at Memorial Sloan Kettering Cancer Center in New York City, and lead author of the AUA guideline.
“One goal of the AUA guideline is to outline criteria to determine who has a bona fide testosterone deficiency, how to evaluate and determine who should be treated,” he tells EndocrineWeb.
Similarly, the Endocrine Society updated their best practices guidance for testosterone therapy in men with hypogonadism, a form of testosterone deficiency.
These clinical recommendations were prepared in response to a “much higher quality of evidence published in recent years about testosterone deficiency and a wider availability of high-quality assays for measuring testosterone levels, which had been a problematic issue,” said Shalendar Bhasin, MD, professor of Medicine at Harvard Medical School, and director of Men’s Health, Research Program at Brigham and Women’s Hospital, in Boston Massachusetts, who led the work on the Endocrine Society project.
How Does Low Testosterone Differ from a Hormonal Deficiency?
Testosterone—a hormone produced primarily in testicles but also to a lesser extent by the ovaries and adrenal cortex—is essential for a variety of physical, cognitive, sexual, and metabolic functions in men. This sex hormone usually peaks in adolescence and early adulthood. As men age, the ability to produce testosterone begins to decline such that testosterone levels begin to drop about 1 to 3 percent a year beginning around age 40 years.
This natural decline, however, does not imply that a man is testosterone deficient or a candidate for testosterone therapy.1,2 A deficiency in this hormone only occurs in cases where there is a low level of testosterone along with specific symptoms or signs.
“Testosterone deficiency is a very specific clinical condition that is defined by the presence of a set of specific signs and symptoms that occur as a result of decreased production of testosterone by the testes in men,” says Dr. Bhasin. “It’s extremely important that testosterone is used only as Food and Drug Administration-approved treatment for this condition.
“What’s been happening over the past couple of years is that there has been a rise in off-label use of testosterone to treat a variety of age-related conditions and symptoms that don’t qualify as a testosterone deficiency,” he says.
Diagnosing and Testing for Hypogonadism
Outside of age, there are “myriad causes for testosterone deficiency,” Dr. Mulhall adds. “They include testicular dysfunction, chemotherapy or radiation to testes, or loss of the testes,” he said. Then there are secondary testosterone deficiencies, genetic disorders, Kleinfelter syndrome, pituitary disorders, steroid use, opioid use, diabetes, and obesity.
While testosterone supplementation is being used to treat low hypoactive sexual desire, a type of sexual dysfunction, in women, “we don’t know if it’s a bona fide condition,” says Dr. Bhasin. It’s been plausible but remains only a hypothesis that hasn’t been proven definitively.
According to the recommendations issued by both the Endocrine Society and AUA,1,2 before a diagnosis of testosterone deficiency can be made, patients must demonstrate both a low testosterone levels and show signs and/or symptoms of the condition.
Signs and Symptoms Signaling a Problem:2,3
Red flag symptoms:
- Low sex drive
- Difficulty with erection
- Low sperm count
- Unexplained loss of hair
- Hot flashes
- Low bone density
Additional signs:
- Testicular atrophy (changes in testes)
- Diminished lean muscle mass
- Increased body fat
- Elevated hemoglobin A1c
- Osteopenia or low trauma bone fracture
- Problems sleeping (insomnia)
- Fatigue
- Difficulty concentrating, lack of motivation, depression
When and How Should a Low Testosterone be Treated?
“Testosterone replacement shouldn’t be used to treat a naturally occurring, age-related decline in this hormone or simply for a low T number,” says Dr. Bhasin, “but if a man has a testosterone deficiency or classical hypogonadism, the benefits of treating the condition with testosterone is favorable and outweighs any risks.”
According to Dr. Bhasin, over the last two to three years there has been greater availability of high-quality lab providing good results for testosterone levels, which until recently has been a problem when trying to make a firm diagnosis.
To confirm the existence of low testosterone requiring treatment, the patient should have two separate blood tests on nonconsecutive days in the early morning (testosterone levels fluctuate during the day and are highest in the early hours) that are analyzed by reliable laboratories certified by the Centers for Disease Control and Prevention, Dr. Bhasin told EndocrineWeb.
A normal range for testosterone levels is 300 ng/dL to 1,000 ng/dL, with the Endocrine Society considering low testosterone below 263 ng/dL, says Dr. Bhasin.
Your doctors should also determine if you (your spouse) show signs or symptoms of a testosterone deficiency. One problem with the symptoms for testosterone deficiency is many are “incredibly nonspecific” Dr. Mulhall cautions, which is why getting accurate testosterone levels is vital.
“If a man had a testosterone level less than 220 and shows signs of osteopenia, the testosterone is low because the patient has bone density loss,” says Dr. Mulhall, “but you can’t just go on the number alone.”
Monitoring, Managing, and Follow-Up Care
Both sets of guidelines stress the importance of monitoring T levels during treatment to make sure the hormone falls within the desired range and to check the status of other health conditions such as sex, heart, and bone health.
“While the number of men using testosterone has increased, it’s concerning that about 20 to 25 percent of men who go on testosterone never get their levels double checked before treatment, and a percentage of men who go on testosterone who don’t get their levels checked at all while they’re on the treatment,” says Dr. Mulhall.
There are a number of health reasons to monitor testosterone treatments. For example, low testosterone is a risk factor for cardiovascular events, but “giving a patient [supplemental] testosterone cannot be said to definitively raise or lower the risk for cardiovascular issues,” Dr. Mulhall says.
While testosterone replacement therapy does not cause prostate cancer, Dr. Bhasin notes that increasing testosterone could raise PSA levels, which may lead to an increased risk for prostate cancer, particularly in the 30% of men over 70 years of age who may have an early-stage prostate that has not yet become detectable.4
“One important goal of monitoring testosterone levels is to minimize the risk of unnecessary biopsies,” he adds.
Know the Health Warnings of T Supplementation
When it comes to treatment, there are a variety of forms of testosterone—from gels to adhesive pellets to injections—that can be administered to men.
However, you should be aware that patients who use transdermal gels to restore normal T levels should be careful to avoid any risk of transferring testosterone gels to women and children.4 Covering the shoulders or upper arms where the gel has been applied is sufficient to protect against accidental exposure of this hormone to others.
From a reproductive standpoint, both professional organization guidelines note that men who are trying to conceive should not receive testosterone treatments because it impairs sperm production.
“Even when testosterone replacement is stopped, there will be a period of time during which it will take sperm production a while to recover,” says Dr. Mulhall.
“There’s no magic to diagnosing or treating testosterone deficiency,” says Bhasin. “Like any other condition it’s really important to have accurate measurements and be rigorous in the diagnosis and a major concern has been starting treatments without an appropriate diagnosis.
What is Test Enanthate?
https://go.drugbank.com/drugs/DB13944
https://en.wikipedia.org/wiki/Testosterone_(medication)
https://steroids.click/buy/testosterone-enanthate-usa/
Testosterone Enanthate is an anabolic steroid that is slowly released and has a long half-life (10 days). The steroid stimulates protein synthesis for rapid muscle building. Along with this, the athlete obtains more power. In addition, Testosterone Enanthate stimulates regeneration processes. As a result, the athlete receives an increase in muscle tone, a burst of energy, and quickly recovers from grueling workouts.
Dosage: For a beginner who wants to use Testosterone Enanthate solo for 12 weeks, a dose of 300-500 mg per week will be sufficient. Experienced bodybuilders sometimes take up to 1000 mg of the drug per week.
Bulking Cycle: For weight gain, Testosterone Enanthate is taken with such anabolic steroids as Deca Durabolin or Dianabol. This combination is suitable for beginners and experienced bodybuilders.
Cutting Cycle: For drying, it is worth adding an aromatase inhibitor to Testosterone Enanthate, which will control excessive bloating and water retention. In this case, for the normal functioning of the body, the steroid is used in minimal doses: 100 mg per week.
Testosterone enanthate, sold under the brand names Delatestryl and Xyosted among others, is an androgen and anabolic steroid (AAS) drug which is utilized for the most part in the treatment of low testosterone levels in men. It is additionally utilized in hormone treatment for transgender men. It is given by injection into the muscle for the most part once every one to about a month. It was presented for clinical use in 1954. Alongside testosterone cypionate, testosterone undecanoate, and testosterone propionate, it is one of the most broadly utilized testosterone esters. Notwithstanding its clinical use, testosterone enanthate is utilized to improve build and execution. Medication is a controlled substance in numerous nations thus non-clinical use is commonly illegal.
Uses of Testosterone Enanthate in Human Body
Testosterone enanthate is utilized in men who don’t make a sufficient regular substance called testosterone. In guys, testosterone is liable for some, typical capacities, including development and improvement of the private parts, muscles, and bones. It likewise helps cause an ordinary sexual turn of events (puberty) in young men. Testosterone has a place with a class of medications known as androgens. It works by influencing many-body frameworks so the body can create and work ordinarily. It might likewise be utilized in certain pre-adult young men to cause puberty in those with postponed puberty. It might likewise be utilized to treat particular kinds of breast cancer in ladies.
Misusing or Overdosing Testosterone Enanthate
Abuse or maltreatment of testosterone enanthate can cause genuine symptoms, for example, coronary illness (counting respiratory failure), stroke, liver sickness, mental/state of mind issues, unusual medication looking for the conduct, or ill-advised bone development (in young people). Try not to expand your dose or utilize this medication more regularly or for longer than recommended. At the point when testosterone is abused or manhandled, you may have withdrawal side effects, (for example, discouragement, fractiousness, tiredness) when you out of nowhere quit utilizing the medication. These manifestations may last from weeks to months.
- Chest pain.
- Shortness of breath.
- Swelling in the ankles or feet.
- Seizures.
- Mood swings.
- Increased frequency of erections.
- Painful urination.
- High levels of calcium.
Testosterone Enantate 250mg/ ml Solution for Injection
Testosterone Enanthate is a manufactured version of the naturally occurring male sex hormone, testosterone. It is used in adult men for testosterone replacement to treat various health problems caused by a lack of testosterone (male hypogonadism).
What is Test Cypionate?
https://go.drugbank.com/drugs/DB13943
https://en.wikipedia.org/wiki/Testosterone_cypionate
- Depo-Testosterone (testosterone cypionate)
- Delatestryl (testosterone enanthate)
- Aveed (testosterone undecanoate)
- Testopel (testosterone pellet)
- Ditate-DS (testosterone enanthate)
- Depo-Testadiol (estradiol cypionate; testosterone cypionate)
What is Test Propionate?
https://go.drugbank.com/drugs/DB01420
https://en.wikipedia.org/wiki/Testosterone_propionate
https://www.sciencedirect.com/topics/nursing-and-health-professions/testosterone-propionate
Testosterone propionate is a slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles.
Testosterone propionate is a slower-releasing anabolic steroid with a short half-life. This characteristic allows the user to run short testosterone propionate cycles of 8-10 weeks as optimal peak blood plasma levels are achieved at 2-4 weeks.4 It is a synthetic androstane steroid derivative of testosterone in the form of 17β propionate ester of testosterone.2 Testosterone propionate was developed initially by Watson labs, and FDA approved on February 5, 1974. Currently, this drug has been discontinued in humans, but the vet application is still available as an OTC.5
Toxicity
Reports have shown a potential stimulation of cancerous tissue growth. The potential testosterone propionate accumulation in the body produces a high risk of edema secondary to water and sodium retention.7
- TestoPrime – Strongest Testosterone Booster. A 100% natural, safe, and effective daily testosterone supplement. …
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What is SARMS?
Selective androgen receptor modulator
https://en.wikipedia.org/wiki/Selective_androgen_receptor_modulator
Selective androgen receptor modulators or SARMs are a novel class of androgen receptor ligands. They are intended to have the same kind of effects as androgenic drugs but be much more selective in their action,[1] allowing them to be used for more uses than the uses of anabolic steroids. SARMs signifies a new era of tissue-selective androgens with an unknown potential to treat (and possibly cure) several diseases. [2]
What is TRT’s? – Testosterone replacement therapy
Thus, TRT works by bringing your body back to a healthy range for testosterone, which then slowly begins to reverse the symptoms of low T. Once a steady baseline dose of testosterone has been established on TRT, most men notice an improvement in their energy levels, vitality, and quality of life.
What is Test Blend – Sustanon?
prop – short-acting
phenyprop – longer-acting
isocaproate – similar to enanthate and cypionate
decanoate – longest acting ester
NOTE – enzymes liberate different esters at different rates
Sustanon is used to treat confirmed testosterone deficiency in males. The active substances of Sustanon are turned into testosterone by your body. Testosterone is the natural male hormone known as androgen. In men, testosterone produced by the testicles.
** Trenbolone is one of the best steroids for bulking and cutting. It is also used for achieving massive muscle gains. Stack trenbolone with Dianabol, Deca Durabolin, Anadrol, clenbuterol, Winstrol, and Sustanon. This will help you achieve optimal gains at a faster rate.
What is Deca, Durabolin, Nandrolone Decanoate?
Nandrolone decanoate is used for physique- and performance-enhancing purposes by competitive athletes, bodybuilders, and powerlifters.[3] It is consumed by bodybuilders as per 8-12 weeks bulking cycles with some form of Testosterone as a base[34] because, according to the studies: if consumed solo (i.e., without a base); it shuts down the natural production of Testosterone by altering blood-testis barrier components.[35] Despite this fact, Nandrolone decanoate is one of the most popular injectable AAS worldwide, and nandrolone esters have been said to be the most popular AAS used by bodybuilders and in sports.[3][17] This is in part due to the high ratio of anabolic to androgenic effects of nandrolone and its weak propensity for androgenic and estrogenic side effects.
https://go.drugbank.com/drugs/DB08804
https://en.wikipedia.org/wiki/Nandrolone
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826677/
Deca Durabolin is a very famous injectable anabolic steroid contained the steroidal hormone Nandrolone and is joined to the enormous Decanoate ester. The Nandrolone hormone initially showed up in 1960 under the exchange name Deca Durabolin. From that point forward various Nandrolone Decanoate adaptations turned out in the market, however, Deca Durabolin remains the most perceived. This steroid is one of the most usually utilized anabolic steroids by the two jocks and execution competitors. As a Nandrolone base, Deca Durabolin is joined to the huge Decanoate ester, which controls the hormone’s discharging action backing it off immensely. This permits the person to utilize the Nandrolone hormone without the requirement for visit infusions. Deca Durabolin conveys a moderately strong anabolic rating, somewhat more noteworthy than testosterone; be that as it may, its complete androgenic movement is a lot lower than testosterone.
Right Amount of Dosage of Deca Durabolin
The ideal dose is somewhere in the range of 200 and 600 mg/week. ( 0.6 ML ) Research has indicated that the best outcomes can be gotten with the admission of 2 mg/pound body weight. The anabolic and resulting development effect of Deca Durabolin in the scope of around 200 to 600 mg/week, increments proportionately to the dosage increment.
If in excess of 600 mg/week is regulated, one beginning seeing the negative effects. Also, at a dosage level over 600 mg/week, the anabolic effect no longer expands proportionately to the dosage increment, so that even 1000 mg/week doesn’t ensure fundamentally preferred outcomes over 600 mg/week!
Most male competitors experience great outcomes by taking 400 mg/week. Steroid novices typically need just 200 mg/week.
Stacking Deca Durabolin with Other Steroids
Deca is an incredible steroid for muscle development and can be joined with numerous different steroids. Deca Durabolin consolidates well for muscle development with Dianabol (D-Bol) and Testoviron Depot. The celebrated Dianabol (D-Bol)/Deca stack brings about fast and solid addition in muscle mass. Most competitors generally take 15-40 mg Dianabol (D-Bol)/day and 200-400 mg or ( 0.4 ML ) Deca/week. Quicker outcomes can be accomplished with 400 mg Deca/week and 500 mg Sustanon/week. Competitors report a colossal increase in quality and muscle mass when taking 400 mg Deca/week, 500 mg Sustanon/week, and 30 mg Dianabol (D-Bol)/day.
Nandrolone decanoate, sold under the brand name Deca-Durabolin among others, is an androgen and anabolic steroid (AAS) medication that is used primarily in the treatment of anemias and wasting syndromes, as well as osteoporosis in menopausal women.
Androgens (Includes Deca-Durabolin) fluid retention
Androgenic anabolic steroids may cause sodium and water retention, particularly when given in high dosages or for prolonged periods.
NPP 200 Nandrolone Phenylpropionate
https://en.wikipedia.org/wiki/Nandrolone
Nandrolone phenylpropionate (NPP), or nandrolone phenpropionate, sold under the brand name Durabolin among others, is an androgen and anabolic steroid (AAS) medication that has been used primarily in the treatment of breast cancer and osteoporosis in women. It is given by injection into a muscle once every week. Although it was widely used in the past, the drug has mostly been discontinued and hence is now mostly no longer available.
Side effects of NPP include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire.[3] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT).[3][12] It has strong anabolic effects and weak androgenic effects, which give it a mild side effect profile and make it especially suitable for use in women and children.[3][12][13] NPP is a nandrolone ester and a long-lasting prodrug of nandrolone in the body.[3]
NPP was first described in 1957 and was introduced for medical use in 1959.[3] It was the first nandrolone ester to be introduced, followed by nandrolone decanoate in 1962, and has been one of the most widely used nandrolone esters.[3][14] However, in more recent times, the drug has been largely superseded by nandrolone decanoate, which is longer-acting and more convenient to use.[3][11] In addition to its medical use, NPP is used to improve physique and performance.[3] The drug is a controlled substance in many countries and so non-medical use is generally illicit.[3]
https://en.wikipedia.org/wiki/Nandrolone_decanoate
Equipoise, Boldenone Undecylenate
Equipoise (Boldenone Undecylenate Injection) is recommended as an aid for treating debilitated horses when an improvement in weight, hair coat, or general physical condition is desired. Debilitation often follows disease or may occur following overwork and overexertion.
Primabolon, Enanthate Easter
The drug is what is known as a dihydrotestosterone-based anabolic steroid (or DHT).
Metenolone enanthate, or methenolone enanthate, sold under the brand names Primobolan Depot and Nibal Injection, is an androgen and anabolic steroid (AAS) medication that is used mainly in the treatment of anemia due to bone marrow failure. It is given by injection into a muscle.
https://en.wikipedia.org/wiki/Drostanolone_propionate
Drostanolone Propionate
Because of its strong anti-estrogenic properties, Masteron was used as a treatment for inoperable breast cancer but increased in popularity as a bodybuilding agent that athletes use in preparation for a competition.
Masteron is DHT (dihydrotestosterone) derivative. It is an injectable anabolic steroid. … On the other hand, Masteron Enanthate is the slower, but longer-acting anabolic steroids. Masteron Enanthate contains an ester attached to the drostanolone that is responsible for the slower, but longer release of the hormone.
Muscle hardening and growth. … Many reports that Masteron helps to improve energy levels when they’re at the gym or when they’re at home. It also helps to speed up metabolism and can boost the amount of energy that your cells produce. It helps with cutting.
Masteron Enanthate works best when it is stacked with other anabolic steroids versus being used alone. … It is mainly used in bulking cycles, but there is also a place for it in cutting cycles.
- Increased hemoglobin.
- Darkening and thickening of hair.
- Increase in levels of IGF-1 and MGF hormones.
- Increased collagen synthesis.
- Increased bone mineral content.
- Anti-catabolic effect on muscle tissues.
- Heightened self-esteem.
- Deeper voice.
Masteron is best used for cycles of no longer than 8 weeks in dosages of 300-600 mg/week.
What is the difference between trenbolone acetate ester and Trenbolone Enanthate?
The primary difference between these two forms of Trenbolone boils down to esters. While Tren E has relatively fewer esters, it peaks more slowly and therefore leaves the body slower. Conversely, as Trenbolone Acetate has much more esters, it peaks much quicker and leaves your system quicker.
https://en.wikipedia.org/wiki/Trenbolone
Trenbolone is an androgen and anabolic steroid (AAS) of the nandrolone group which itself was never marketed.[1][2][3][4][5] Trenbolone ester prodrugs, including trenbolone acetate (brand names Finajet, Finaplix, others) and trenbolone hexahydrobenzylcarbonate (brand names Parabolan, Hexabolan), are or have been marketed for veterinary and clinical use.[1][2][3][5][6][7] Trenbolone acetate is used in veterinary medicine in livestock to increase muscle growth and appetite, while trenbolone hexahydrobenzylcarbonate was formerly used clinically in humans but is now no longer marketed.[1][2][3][5] In addition, although it is not approved for clinical or veterinary use, trenbolone enanthate is sometimes sold on the black market under the nickname Trenabol.[5]
Prednisone has a tendency to raise the level of glucose, or sugar, in the blood, which can cause increased body fat or diabetes in some people. It is important to avoid “simple” carbohydrates and concentrated sweets, such as cakes, pies, cookies, jams, honey, chips, bread, candy, and other highly processed foods. Prednisone can increase the risk of gastrointestinal disturbance. Long-term use of alcohol causes inflammation of the stomach lining, which can lead to stomach ulcers, heartburn, and malnutrition. People with existing stomach issues, such as heartburn, should avoid using prednisone and alcohol together.
Trenbolone Enanthate
https://en.wikipedia.org/wiki/Trenbolone_acetate
Tren 100 Tren Ace, Tren Enanthate
Trenbolone acetate was never approved for use in humans and therefore guidelines for human consumption do not exist.[5] However, athletes and bodybuilders have been using trenbolone acetate as a physique- and performance-enhancing drug for decades. There are a large number of benefits as a bodybuilder through using trenbolone acetate as an AAS. Unlike testosterone, trenbolone acetate does not cause any fluid retention while gaining muscle mass.[11] This allows bodybuilders to appear leaner, and this is why it is more commonly used whilst preparing for competitive events. Trenbolone acetate does not convert into an estrogenic metabolite,[11] and this results in a lack of estrogenic side effects.[5] Trenbolone enanthate is also a very commonly used AAS and lasts much longer than trenbolone acetate with intramuscular injection.[5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700702/
Sustanon is used to treat confirmed testosterone deficiency in males. The active substances of Sustanon are turned into testosterone by your body. Testosterone is the natural male hormone known as androgen. In men, testosterone produced by the testicles. Sustanon (Su) is an oil-based injectable anabolic–androgenic steroid (AAS) typically containing four different testosterone esters (testosterone propionate, testosterone phenylpropionate, testosterone isocaproate, and testosterone decanoate), which provides a continuous release of testosterone into the blood and produces a stable testosterone level for a prolonged period extending for 3–4 weeks.
AASs are a group of synthetic compounds structurally related to testosterone, which are pharmacologically important for the treatment of hypogonadism, impotence, delayed puberty, muscle wasting, diaphragm atrophy, osteoporosis, types of anemia, endometriosis and fibrocystic breast disease, alcohol hepatitis, wound and burn healings, and finally, renal failure [3–7]. In addition to their therapeutic uses, AASs are also taken in high doses by athletes, bodybuilders, and youths to enhance muscle mass or physical endurance [8]. Uncontrolled usage of AASs may lead to serious side effects, such as cardiovascular disorder (particularly enlargement of the left ventricle), which can lead to sudden death, acute hepatitis and jaundice, testicular dysfunction, which leads to infertility, hypertension, and behavioral disorders [9, 10]. Abusing AAS by many bodybuilders, athletes, and the youth is a serious health phenomenon that has recently increased rapidly [11, 12].
What is hCG?
Human chorionic gonadotropin (hCG) is sometimes called “the pregnancy hormone” because of its important role in maintaining pregnancy.
Pregnancy tests check hCG levels in the urine or blood to determine if a person is pregnant or not.
The Food and Drug Administration (FDA) has also approved hCG injections to treat specific medical conditions in both women and men.
In women, hCG injections are FDA approved to help treat infertility.
In men, hCG injections are FDA approved for a type of hypogonadism in which the body doesn’t adequately stimulate the gonads to produce the sex hormone testosterone.
There are a variety of reasons why a doctor might prescribe hCG to a man.
To help address hypogonadism
In men, doctors prescribe hCG to help address the symptoms of hypogonadism, such as low testosterone and infertility. hCG can help the body increase its production of testosterone and sperm, which can help reduce infertility.
To improve testosterone deficiency
Injections of hCG are also sometimes used as an alternative to testosterone products in men with testosterone deficiency.
Testosterone deficiency is defined as testosterone blood levels less than 300 nanograms per deciliter (ng/dL) along with symptoms of low testosterone. These include:
- fatigue
- stress
- a low sex drive
- depressed mood
According to the American Urological Association, hCG is appropriate for those men with testosterone deficiency who also desire to maintain fertility.
Testosterone products boost levels of the hormone in the body but can have the side effects of shrinking the gonads, altering sexual function, and causing infertility.
hCG can help increase:
- gonad size
- testosterone levels
- fertility
Some doctors believe that using testosterone along with hCG may help improve symptoms of testosterone deficiency while preventing some of testosterone’s side effects.
To improve sexual function
hCG may also help improve sexual function in men who don’t experience improvement while on testosterone.
To reverse steroid side effects
Bodybuilders who take anabolic steroids such as testosterone also sometimes use hCG to help prevent or reverse some of the side effects steroids cause, such as gonad shrinkage and infertility.
In men, hCG acts like luteinizing hormone (LH). LH stimulates Leydig cells in the testicles, which results in the production of testosterone.
LH also stimulates the production of sperm within structures in the testicles called seminiferous tubules.
As hCG stimulates the testicles to produce testosterone and sperm, the testicles grow in size over time.
What is Green Top GH (Somatropin)?
For HGH injection, you must use Ultra-Fine pen needles, either 29 gauge, 30 gauge, or 31 gauge x 0,6-0,8 mm
MIxing Needle = 10ml/cc Syringes with 18Ga Needles and Caps, Disposable Syringe, Single sterile Individually Packaged (20Pack-10ML) + 5-10ml Empty Sealed Sterile Vials
GH is a single-chain protein made of 191 amino acids with a molecular weight of approximately 22 kDa (Kilo Daltons). It is released into the bloodstream by the somatotrope cells of the anterior pituitary gland. Initially, it was taken from human pituitary glands, however, in 1985, biosynthetic HH replaced this earlier version.
So what is the optimal dose of HGH one should take to attain its benefits? Ali: “To get the full effect of HGH, timing and amount are crucial. Needless to say, the period is taken and consistency is more important than the total amount, as taking a 200 IU kit of HGH over 50 days (at 4 IU a day) is more efficient than taking the same 200 IU over a period of 25 days (at 8 IU a day).”
https://en.wikipedia.org/wiki/Growth_hormone_therapy
- pain, itching, or skin changes where the medicine was injected;
- swelling, rapid weight gain;
- muscle or joint pain;
- numbness or tingling;
- stomach pain, gas;
- headache, back pain; or.
- cold or flu symptoms, stuffy nose, sneezing, sore throat, ear pain.
…
Common side effects include:
- low blood sodium (hyponatremia),
- fluid overload,
- fluid absorption, and.
- electrolyte imbalance.
Growth hormone, which is highly anabolic, increases skeletal muscle mass and reduces body fat and therefore is used especially by strength and power sports athletes.
- Improved skin barrier.
- Reduced wrinkles. Collagen can plump skin and lips, and when skin is firmer and plumper, wrinkles and fine lines will be less visible.
- More elastic skin. …
- Eases inflammation. …
- Can help clear breakouts.
Peptides (from Greek language πεπτός, peptós “digested”; derived from πέσσειν, péssein “to digest”) are short chains of between two and fifty amino acids, linked by peptide bonds.[1][2] Chains of fewer than ten or fifteen amino acids are called oligopeptides and include dipeptides, tripeptides, and tetrapeptides.
A polypeptide is a long, continuous, unbranched peptide chain of up to approximately fifty amino acids.[3] Hence, peptides fall under the broad chemical classes of biological polymers and oligomers, alongside nucleic acids, oligosaccharides, polysaccharides, and others.
A polypeptide that contains more than approximately fifty amino acids is known as a protein.[3][4][5] Proteins consist of one or more polypeptides arranged in a biologically functional way, often bound to ligands such as coenzymes and cofactors, or to another protein or other macromolecules such as DNA or RNA, or too complex macromolecular assemblies.[6]
Amino acids that have been incorporated into peptides are termed residues. A water molecule is released during the formation of each amide bond.[7] All peptides except cyclic peptides have an N-terminal (amine group) and C-terminal (carboxyl group) residue at the end of the peptide (as shown for the tetrapeptide in the image).
List of all peptides at:
A peptide is a short-chain made up of two or more amino acids. The amino acids are linked by a chemical bond called a peptide bond. When organized in complex structures (typically consisting of 50 or more amino acids), peptides then become proteins. Peptides have several functions in the body. They are also the basis of various medications.
Begin in Your Mid ’20s or Early ’30s
“Your mid-twenties are a great time to start using retinol,” says Ellen Marmur, M.D. “Many patients who have used it for years swear by it.”
HGH * Lose fat, gain muscle * Increase energy level * Increase immune function * Enhance sexual performance * Increase cardiac output * Improve skin elasticity * Remove wrinkles * Eliminate cellulite * Improve vision * Increase memory retention * Improve the quality of sleep * Increase exercise performance * Lower blood pressure * Improve cholesterol profile * Increase bone mass * Quicken wound healing Growth hormone (GH) is a peptide hormone. It stimulates growth and cell reproduction in humans and other animals. It is a 191-amino acid, single-chain polypeptide hormone which is synthesized, stored, and secreted by the somatotroph cells within the lateral wings of the anterior pituitary gland. Somatotrophin refers to the growth hormone produced natively in animals, the term refers to growth hormone produced by recombinant DNA technology and is abbreviated “rhGH” in humans. GH can be used to treat conditions that produce short stature but are not related to deficiencies in GH, though results are not as dramatic when compared to short stature solely due to deficiency of GH. Examples of other causes of shortness often treated with GH are Turner syndrome, chronic renal failure, Prader-Willi syndrome, intrauterine growth retardation, and severe idiopathic short stature. Higher (“pharmacologic”) doses are required to produce significant acceleration of growth in these conditions, producing blood levels well above physiologic. Despite the higher doses, side effects during treatment are rare and vary little according to the condition being treated. GH treatment improves muscle strength and slightly reduces body fat in Prader-Willi syndrome, which are significant concerns beyond the need to increase height. GH is also useful in maintaining muscle mass in wasting due to AIDS. GH can also be used in patients with short bowel syndrome to lessen the requirement for intravenous total parenteral nutrition.
*Disclaimer: This information is not intended to be a substitute for professional medical advice. You should not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider.
Please consult your healthcare provider with any questions or concerns you may have regarding your condition.
The information provided is for educational purposes only and is not intended as a diagnosis, treatment, or prescription of any kind. The decision to use, or not to use, any information is the sole responsibility of the reader. These statements are not expressions of legal opinion relative to the scope of practice, medical diagnosis, or medical advice, nor do they represent an endorsement of any product, company, or specific massage therapy technique, modality, or approach. All trademarks, registered trademarks, brand names, registered brand names, logos, and company logos referenced in this post are the property of their owners.
